Using any of these substances in conjunction with using Cannabis may expose the body to harmful substances and increase the unwanted side effects of Cannabis. Cannabis may have a sleepiness or drowsing effect, and its combination with alcohol may cause an increased blurring effect. As for smoking tobacco, the smoking of Cannabis inflorescent together with tobacco may impact the medicinal effect of the Cannabis since the combustion temperature of tobacco is higher than that of the Cannabis, which in turn impairs the availability of the active ingredient, therefore the combination of the two is not recommended.